Journalartikel

Jahr der Veröffentlichung: 2015

Seiten: 161-164

Zeitschrift: Cytokine

Bandnummer: 71

Heftnummer: 2

ISSN: 1043-4666

DOI Link: https://doi.org/10.1016/j.cyto.2014.10.015

Verlag: Elsevier

Abstract: 
Objective: Pref-1 has recently been introduced as a novel insulin resistance-inducing adipokine influencing adipogenesis. The role of circulating Pref-1 in patients with gestational diabetes mellitus (GDM) has not been assessed so far.Methods: We determined circulating Pref-1 serum levels in 74 patients with GDM, as well as 74 healthy age-, body mass index (BMI-), and gestational age-matched pregnant controls. Furthermore, Pref-1 was correlated with anthropometric measures, as well as biochemical markers, of glucose homeostasis, lipid metabolism, renal function, and inflammation.Results: Mean serum Pref-1 levels during pregnancy were not significantly different between patients with GDM (0.40 mu g/l) and healthy controls (0.42 mu g/l) (p = 0.655). Multivariate analysis revealed that gestational age at blood sampling, triglycerides (TG), and creatinine independently and positively predicted Pref-1 levels (p < 0.05). Furthermore, Pref-1 levels were independently and negatively associated with BMI and C reactive protein (p <0.05).Conclusions: Pref-1 is probably not a major contributor to GDM pathophysiology but might directly contribute to TG metabolism, as well as depend on gestational age and renal function. (C) 2014 Elsevier Ltd. All rights reserved.

Harvard-Zitierstil: Wurst, U., Ebert, T., Kralisch, S., Stumvoll, M. and Fasshauer, M. (2015) Serum levels of the adipokine Pref-1 in gestational diabetes mellitus, Cytokine, 71(2), pp. 161-164. https://doi.org/10.1016/j.cyto.2014.10.015

APA-Zitierstil: Wurst, U., Ebert, T., Kralisch, S., Stumvoll, M., & Fasshauer, M. (2015). Serum levels of the adipokine Pref-1 in gestational diabetes mellitus. Cytokine. 71(2), 161-164. https://doi.org/10.1016/j.cyto.2014.10.015