Journal article

Publication year: 2015

Pages: 161-164

Journal: Cytokine

Volume number: 71

Issue number: 2

ISSN: 1043-4666

DOI Link: https://doi.org/10.1016/j.cyto.2014.10.015

Publisher: Elsevier

Abstract: 
Objective: Pref-1 has recently been introduced as a novel insulin resistance-inducing adipokine influencing adipogenesis. The role of circulating Pref-1 in patients with gestational diabetes mellitus (GDM) has not been assessed so far.Methods: We determined circulating Pref-1 serum levels in 74 patients with GDM, as well as 74 healthy age-, body mass index (BMI-), and gestational age-matched pregnant controls. Furthermore, Pref-1 was correlated with anthropometric measures, as well as biochemical markers, of glucose homeostasis, lipid metabolism, renal function, and inflammation.Results: Mean serum Pref-1 levels during pregnancy were not significantly different between patients with GDM (0.40 mu g/l) and healthy controls (0.42 mu g/l) (p = 0.655). Multivariate analysis revealed that gestational age at blood sampling, triglycerides (TG), and creatinine independently and positively predicted Pref-1 levels (p < 0.05). Furthermore, Pref-1 levels were independently and negatively associated with BMI and C reactive protein (p <0.05).Conclusions: Pref-1 is probably not a major contributor to GDM pathophysiology but might directly contribute to TG metabolism, as well as depend on gestational age and renal function. (C) 2014 Elsevier Ltd. All rights reserved.

Harvard Citation style: Wurst, U., Ebert, T., Kralisch, S., Stumvoll, M. and Fasshauer, M. (2015) Serum levels of the adipokine Pref-1 in gestational diabetes mellitus, Cytokine, 71(2), pp. 161-164. https://doi.org/10.1016/j.cyto.2014.10.015

APA Citation style: Wurst, U., Ebert, T., Kralisch, S., Stumvoll, M., & Fasshauer, M. (2015). Serum levels of the adipokine Pref-1 in gestational diabetes mellitus. Cytokine. 71(2), 161-164. https://doi.org/10.1016/j.cyto.2014.10.015