Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: 766-773

Zeitschrift: International Journal of Obesity

Bandnummer: 36

Heftnummer: 6

ISSN: 0307-0565

DOI Link: https://doi.org/10.1038/ijo.2011.162

Verlag: Springer Nature [academic journals on nature.com]

Abstract: 
Background: Adipocyte fatty acid-binding protein (AFABP) was recently introduced as a novel adipokine playing an important role in glucose homeostasis. In this study, we investigated the relationship between serum AFABP levels and metabolic, as well as cardiovascular parameters, in the self-contained population of Sorbs. Furthermore, we conducted a genome-wide association study on serum AFABP concentrations in the Sorbs and we separately analyzed the effects of two common variants in the FABP4 gene on AFABP serum concentration.Methods: Serum AFABP concentrations were quantified by enzyme-linked immunosorbent assay and correlated with metabolic and cardiovascular parameters, as well as inflammatory markers and renal function, in 868 well-characterized non-diabetic Sorbs from Germany.Results: Median AFABP serum concentrations were 1.5-fold higher in female subjects (23.03 mu g l(-1)) as compared to male subjects (15.86 mu g l(-1)). Waist-to-height ratio and glomerular filtration rate were independently associated with AFABP concentrations in multiple regression analysis in both female and male subjects. The genome-wide scan for association of single-nucleotide polymorphisms with serum AFABP levels in the Sorbs revealed 39 loci reaching P-values < 10(-4). Two single-nucleotide polymorphisms, rs16909187 and rs10808846, representing common genetic variation in FABP4 did not show any effect on serum AFABP concentrations in our study cohort.Conclusion: AFABP serum concentrations are determined by parameters of fat distribution, renal function and gender. International Journal of Obesity (2012) 36, 766-773; doi:10.1038/ijo.2011.162; published online 23 August 2011

Harvard-Zitierstil: Tönjes, A., Kralisch, S., Lössner, U., Kovacs, P., Blüher, M., Stumvoll, M., et al. (2012) Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein, International Journal of Obesity, 36(6), pp. 766-773. https://doi.org/10.1038/ijo.2011.162

APA-Zitierstil: Tönjes, A., Kralisch, S., Lössner, U., Kovacs, P., Blüher, M., Stumvoll, M., & Fasshauer, M. (2012). Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein. International Journal of Obesity. 36(6), 766-773. https://doi.org/10.1038/ijo.2011.162