Journal article

Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein


Authors listTönjes, A; Kralisch, S; Lössner, U; Kovacs, P; Blüher, M; Stumvoll, M; Fasshauer, M

Publication year2012

Pages766-773

JournalInternational Journal of Obesity

Volume number36

Issue number6

ISSN0307-0565

DOI Linkhttps://doi.org/10.1038/ijo.2011.162

PublisherSpringer Nature [academic journals on nature.com]


Abstract
Background: Adipocyte fatty acid-binding protein (AFABP) was recently introduced as a novel adipokine playing an important role in glucose homeostasis. In this study, we investigated the relationship between serum AFABP levels and metabolic, as well as cardiovascular parameters, in the self-contained population of Sorbs. Furthermore, we conducted a genome-wide association study on serum AFABP concentrations in the Sorbs and we separately analyzed the effects of two common variants in the FABP4 gene on AFABP serum concentration.Methods: Serum AFABP concentrations were quantified by enzyme-linked immunosorbent assay and correlated with metabolic and cardiovascular parameters, as well as inflammatory markers and renal function, in 868 well-characterized non-diabetic Sorbs from Germany.Results: Median AFABP serum concentrations were 1.5-fold higher in female subjects (23.03 mu g l(-1)) as compared to male subjects (15.86 mu g l(-1)). Waist-to-height ratio and glomerular filtration rate were independently associated with AFABP concentrations in multiple regression analysis in both female and male subjects. The genome-wide scan for association of single-nucleotide polymorphisms with serum AFABP levels in the Sorbs revealed 39 loci reaching P-values < 10(-4). Two single-nucleotide polymorphisms, rs16909187 and rs10808846, representing common genetic variation in FABP4 did not show any effect on serum AFABP concentrations in our study cohort.Conclusion: AFABP serum concentrations are determined by parameters of fat distribution, renal function and gender. International Journal of Obesity (2012) 36, 766-773; doi:10.1038/ijo.2011.162; published online 23 August 2011



Citation Styles

Harvard Citation styleTönjes, A., Kralisch, S., Lössner, U., Kovacs, P., Blüher, M., Stumvoll, M., et al. (2012) Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein, International Journal of Obesity, 36(6), pp. 766-773. https://doi.org/10.1038/ijo.2011.162

APA Citation styleTönjes, A., Kralisch, S., Lössner, U., Kovacs, P., Blüher, M., Stumvoll, M., & Fasshauer, M. (2012). Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein. International Journal of Obesity. 36(6), 766-773. https://doi.org/10.1038/ijo.2011.162


Last updated on 2025-21-05 at 16:22