Journalartikel

Jahr der Veröffentlichung: 2013

Seiten: 6994-7003

Zeitschrift: Organic & Biomolecular Chemistry

Bandnummer: 11

Heftnummer: 40

ISSN: 1477-0520

DOI Link: https://doi.org/10.1039/c3ob41215f

Verlag: Royal Society of Chemistry

Abstract: 
Gram-negative bacteria often use N-acyl-honnoserine lactones (AHLs) as signal molecules to monitor their local population densities and to regulate gene-expression in a process called "Quorum Sensing" (QS). This cell-to-cell communication allows bacteria to adapt to environmental changes and to behave as multicellular communities. QS plays a key role in both bacterial virulence towards the host and symbiotic interactions with other organisms. Plants also perceive AHLs and respond to them with changes in gene expression or modifications in development. Herein, we report the synthesis of new AHL-derivatives for the investigation and identification of AHL-interacting proteins. We show that our new compounds are still recognised by different bacteria and that a novel biotin-tagged-AHL derivative interacts with a bacterial AHL receptor.

Harvard-Zitierstil: Thomanek, H., Schenk, S., Stein, E., Kogel, K., Schikora, A. and Maison, W. (2013) Modified N-acyl-homoserine lactones as chemical probes for the elucidation of plant-microbe interactions, Organic and Biomolecular Chemistry, 11(40), pp. 6994-7003. https://doi.org/10.1039/c3ob41215f

APA-Zitierstil: Thomanek, H., Schenk, S., Stein, E., Kogel, K., Schikora, A., & Maison, W. (2013). Modified N-acyl-homoserine lactones as chemical probes for the elucidation of plant-microbe interactions. Organic and Biomolecular Chemistry. 11(40), 6994-7003. https://doi.org/10.1039/c3ob41215f