Journal article

Publication year: 2013

Pages: 6994-7003

Journal: Organic & Biomolecular Chemistry

Volume number: 11

Issue number: 40

ISSN: 1477-0520

DOI Link: https://doi.org/10.1039/c3ob41215f

Publisher: Royal Society of Chemistry

Abstract: 
Gram-negative bacteria often use N-acyl-honnoserine lactones (AHLs) as signal molecules to monitor their local population densities and to regulate gene-expression in a process called "Quorum Sensing" (QS). This cell-to-cell communication allows bacteria to adapt to environmental changes and to behave as multicellular communities. QS plays a key role in both bacterial virulence towards the host and symbiotic interactions with other organisms. Plants also perceive AHLs and respond to them with changes in gene expression or modifications in development. Herein, we report the synthesis of new AHL-derivatives for the investigation and identification of AHL-interacting proteins. We show that our new compounds are still recognised by different bacteria and that a novel biotin-tagged-AHL derivative interacts with a bacterial AHL receptor.

Harvard Citation style: Thomanek, H., Schenk, S., Stein, E., Kogel, K., Schikora, A. and Maison, W. (2013) Modified N-acyl-homoserine lactones as chemical probes for the elucidation of plant-microbe interactions, Organic and Biomolecular Chemistry, 11(40), pp. 6994-7003. https://doi.org/10.1039/c3ob41215f

APA Citation style: Thomanek, H., Schenk, S., Stein, E., Kogel, K., Schikora, A., & Maison, W. (2013). Modified N-acyl-homoserine lactones as chemical probes for the elucidation of plant-microbe interactions. Organic and Biomolecular Chemistry. 11(40), 6994-7003. https://doi.org/10.1039/c3ob41215f