Journalartikel

Jahr der Veröffentlichung: 2022

Seiten: eabh1623-

Zeitschrift: Science

Bandnummer: 376

Heftnummer: 6590

ISSN: 0036-8075

eISSN: 1095-9203

Open Access Status: Green

DOI Link: https://doi.org/10.1126/science.abh1623

Verlag: American Association for the Advancement of Science

Abstract: 
Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition. Here, we measured the lipidomes and transcriptomes of individual human dermal fibroblasts by coupling high-resolution mass spectrometry imaging with single-cell transcriptomics. We found that the cell-to-cell variations of specific lipid metabolic pathways contribute to the establishment of cell states involved in the organization of skin architecture. Sphingolipid composition is shown to define fibroblast subpopulations, with sphingolipid metabolic rewiring driving cell-state transitions. Therefore, cell-to-cell lipid heterogeneity affects the determination of cell states, adding a new regulatory component to the self-organization of multicellular systems.

Harvard-Zitierstil: Capolupo, L., Khven, I., Lederer, A., Mazzeo, L., Glousker, G., Ho, S., et al. (2022) Sphingolipids control dermal fibroblast heterogeneity, Science, 376(6590), p. eabh1623. https://doi.org/10.1126/science.abh1623

APA-Zitierstil: Capolupo, L., Khven, I., Lederer, A., Mazzeo, L., Glousker, G., Ho, S., Russo, F., Montoya, J., Bhandari, D., Bowman, A., Ellis, S., Guiet, R., Burri, O., Detzner, J., Muthing, J., Homicsko, K., Kuonen, F., Gilliet, M., Spengler, B., ...D'Angelo, G. (2022). Sphingolipids control dermal fibroblast heterogeneity. Science. 376(6590), eabh1623. https://doi.org/10.1126/science.abh1623