Journal article

Sphingolipids control dermal fibroblast heterogeneity


Authors listCapolupo, L; Khven, I; Lederer, AR; Mazzeo, L; Glousker, G; Ho, S; Russo, F; Montoya, JP; Bhandari, DR; Bowman, AP; Ellis, SR; Guiet, R; Burri, O; Detzner, J; Muthing, J; Homicsko, K; Kuonen, F; Gilliet, M; Spengler, B; Heeren, RMA; Dotto, GP; La Manno, G; D'Angelo, G

Publication year2022

Pageseabh1623-

JournalScience

Volume number376

Issue number6590

ISSN0036-8075

eISSN1095-9203

Open access statusGreen

DOI Linkhttps://doi.org/10.1126/science.abh1623

PublisherAmerican Association for the Advancement of Science


Abstract
Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition. Here, we measured the lipidomes and transcriptomes of individual human dermal fibroblasts by coupling high-resolution mass spectrometry imaging with single-cell transcriptomics. We found that the cell-to-cell variations of specific lipid metabolic pathways contribute to the establishment of cell states involved in the organization of skin architecture. Sphingolipid composition is shown to define fibroblast subpopulations, with sphingolipid metabolic rewiring driving cell-state transitions. Therefore, cell-to-cell lipid heterogeneity affects the determination of cell states, adding a new regulatory component to the self-organization of multicellular systems.



Citation Styles

Harvard Citation styleCapolupo, L., Khven, I., Lederer, A., Mazzeo, L., Glousker, G., Ho, S., et al. (2022) Sphingolipids control dermal fibroblast heterogeneity, Science, 376(6590), p. eabh1623. https://doi.org/10.1126/science.abh1623

APA Citation styleCapolupo, L., Khven, I., Lederer, A., Mazzeo, L., Glousker, G., Ho, S., Russo, F., Montoya, J., Bhandari, D., Bowman, A., Ellis, S., Guiet, R., Burri, O., Detzner, J., Muthing, J., Homicsko, K., Kuonen, F., Gilliet, M., Spengler, B., ...D'Angelo, G. (2022). Sphingolipids control dermal fibroblast heterogeneity. Science. 376(6590), eabh1623. https://doi.org/10.1126/science.abh1623


Last updated on 2025-10-06 at 11:38