Journalartikel

Jahr der Veröffentlichung: 2020

Zeitschrift: Journal of Functional Foods

Bandnummer: 75

ISSN: 1756-4646

eISSN: 2214-9414

Open Access Status: Gold

DOI Link: https://doi.org/10.1016/j.jff.2020.104268

Verlag: Elsevier

Abstract: 
Milk sialyllactose (SL) and sialic acids (SA) are considered to be crucial for brain composition and development. To investigate their metabolic fate, we administered C-13-labelled 3'SL (C-13-3'SL) and C-13-N-acetylneuraminic acid (C-13-Neu5Ac) to NMRI mice. From per oral and intravenous (i.v.) applications, an organ specific C-13-enrichment can be excluded. The C-13-enrichment after oral application (o.a.) was lowest in brain tissue and not detectable after i.v. in any organ. The presence of C-13-Neu5Ac in urine after the o.a. of both labelled components demonstrated that C-13-Neu5Ac was taken up by gut epithelial cells. Because plasma C-13-enrichment increased over time, when the oral C-13-bolus had reached the lower gastrointestinal tract, an involvement of intestinal epithelial cells and/or gut microbiota in the metabolism of C-13-3'SL and/or C-13-Neu5Ac could be assumed. Hence, SL or Neu5Ac might influence the gut brain axis by effects within the gastrointestinal tract rather than being directly incorporated into the brain.

Harvard-Zitierstil: Galuska, C., Rudloff, S., Kuntz, S., Borsch, C., Reutzel, M., Eckert, G., et al. (2020) Metabolic fate and organ distribution of 13C-3′-sialyllactose and 13C-N-acetylneuraminic acid in wild-type mice – No evidence for direct incorporation into the brain, Journal of Functional Foods, 75, Article 104268. https://doi.org/10.1016/j.jff.2020.104268

APA-Zitierstil: Galuska, C., Rudloff, S., Kuntz, S., Borsch, C., Reutzel, M., Eckert, G., Galuska, S., & Kunz, C. (2020). Metabolic fate and organ distribution of 13C-3′-sialyllactose and 13C-N-acetylneuraminic acid in wild-type mice – No evidence for direct incorporation into the brain. Journal of Functional Foods. 75, Article 104268. https://doi.org/10.1016/j.jff.2020.104268