Journal article

Publication year: 2020

Journal: Journal of Functional Foods

Volume number: 75

ISSN: 1756-4646

eISSN: 2214-9414

Open access status: Gold

DOI Link: https://doi.org/10.1016/j.jff.2020.104268

Publisher: Elsevier

Abstract: 
Milk sialyllactose (SL) and sialic acids (SA) are considered to be crucial for brain composition and development. To investigate their metabolic fate, we administered C-13-labelled 3'SL (C-13-3'SL) and C-13-N-acetylneuraminic acid (C-13-Neu5Ac) to NMRI mice. From per oral and intravenous (i.v.) applications, an organ specific C-13-enrichment can be excluded. The C-13-enrichment after oral application (o.a.) was lowest in brain tissue and not detectable after i.v. in any organ. The presence of C-13-Neu5Ac in urine after the o.a. of both labelled components demonstrated that C-13-Neu5Ac was taken up by gut epithelial cells. Because plasma C-13-enrichment increased over time, when the oral C-13-bolus had reached the lower gastrointestinal tract, an involvement of intestinal epithelial cells and/or gut microbiota in the metabolism of C-13-3'SL and/or C-13-Neu5Ac could be assumed. Hence, SL or Neu5Ac might influence the gut brain axis by effects within the gastrointestinal tract rather than being directly incorporated into the brain.

Harvard Citation style: Galuska, C., Rudloff, S., Kuntz, S., Borsch, C., Reutzel, M., Eckert, G., et al. (2020) Metabolic fate and organ distribution of 13C-3′-sialyllactose and 13C-N-acetylneuraminic acid in wild-type mice – No evidence for direct incorporation into the brain, Journal of Functional Foods, 75, Article 104268. https://doi.org/10.1016/j.jff.2020.104268

APA Citation style: Galuska, C., Rudloff, S., Kuntz, S., Borsch, C., Reutzel, M., Eckert, G., Galuska, S., & Kunz, C. (2020). Metabolic fate and organ distribution of 13C-3′-sialyllactose and 13C-N-acetylneuraminic acid in wild-type mice – No evidence for direct incorporation into the brain. Journal of Functional Foods. 75, Article 104268. https://doi.org/10.1016/j.jff.2020.104268