Journalartikel
Autorenliste: Hassan, HA; Abdelhafez, OH; Shady, NH; Yahia, R; Mohamed, NM; Rateb, ME; Akil, L; Khadra, I; Glaeser, SP; Kämpfer, P; Abdelmohsen, UR; El-Katatny, MH
Jahr der Veröffentlichung: 2023
Seiten: 4063-4068
Zeitschrift: Natural Product Research
Bandnummer: 37
Heftnummer: 23
ISSN: 1478-6419
eISSN: 1478-6427
Open Access Status: Green
DOI Link: https://doi.org/10.1080/14786419.2023.2167204
Verlag: Taylor and Francis Group
Abstract:
Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, Allium cepa was investigated for fungal diversity using different media to give 11 isolates which were identified morphologically. Out of the isolated fungal strains, Penicillium sp. (LCEF10) revealed potential anti-infective activity against the tested microbes (Fusarium solaniATTC 25922, Pseudomonas aeruginosa(ATTC 29231), Staphylococcus aureusATTC 27853, Candida albicansATTC 10231), besides, their MICs were measured by well diffusion method, therefore, it was subjected to molecular identification in addition to phylogenetic analysis. Moreover, the ITS sequence of strain LCEF10 showed a consistent assignment with the highest sequence similarity (99.81%) to Penicillium oxalicum NRRL 787. The crude ethyl acetate extract of Penicillium sp. LCEF10 was investigated for metabolomic analysis using LC-HR-ESI-MS. The metabolic profiling revealed the presence of polyketides, macrolides, phenolics and terpenoids. Furthermore, in silico molecular docking study was carried out to predict which compounds most likely responsible for the anti-infective activity.
Zitierstile
Harvard-Zitierstil: Hassan, H., Abdelhafez, O., Shady, N., Yahia, R., Mohamed, N., Rateb, M., et al. (2023) The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies, Natural Product Research, 37(23), pp. 4063-4068. https://doi.org/10.1080/14786419.2023.2167204
APA-Zitierstil: Hassan, H., Abdelhafez, O., Shady, N., Yahia, R., Mohamed, N., Rateb, M., Akil, L., Khadra, I., Glaeser, S., Kämpfer, P., Abdelmohsen, U., & El-Katatny, M. (2023). The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies. Natural Product Research. 37(23), 4063-4068. https://doi.org/10.1080/14786419.2023.2167204
