Journal article

The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies


Authors list: Hassan, HA; Abdelhafez, OH; Shady, NH; Yahia, R; Mohamed, NM; Rateb, ME; Akil, L; Khadra, I; Glaeser, SP; Kämpfer, P; Abdelmohsen, UR; El-Katatny, MH

Publication year: 2023

Pages: 4063-4068

Journal: Natural Product Research

Volume number: 37

Issue number: 23

ISSN: 1478-6419

eISSN: 1478-6427

Open access status: Green

DOI Link: https://doi.org/10.1080/14786419.2023.2167204

Publisher: Taylor and Francis Group


Abstract: 
Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, Allium cepa was investigated for fungal diversity using different media to give 11 isolates which were identified morphologically. Out of the isolated fungal strains, Penicillium sp. (LCEF10) revealed potential anti-infective activity against the tested microbes (Fusarium solaniATTC 25922, Pseudomonas aeruginosa(ATTC 29231), Staphylococcus aureusATTC 27853, Candida albicansATTC 10231), besides, their MICs were measured by well diffusion method, therefore, it was subjected to molecular identification in addition to phylogenetic analysis. Moreover, the ITS sequence of strain LCEF10 showed a consistent assignment with the highest sequence similarity (99.81%) to Penicillium oxalicum NRRL 787. The crude ethyl acetate extract of Penicillium sp. LCEF10 was investigated for metabolomic analysis using LC-HR-ESI-MS. The metabolic profiling revealed the presence of polyketides, macrolides, phenolics and terpenoids. Furthermore, in silico molecular docking study was carried out to predict which compounds most likely responsible for the anti-infective activity.



Citation Styles

Harvard Citation style: Hassan, H., Abdelhafez, O., Shady, N., Yahia, R., Mohamed, N., Rateb, M., et al. (2023) The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies, Natural Product Research, 37(23), pp. 4063-4068. https://doi.org/10.1080/14786419.2023.2167204

APA Citation style: Hassan, H., Abdelhafez, O., Shady, N., Yahia, R., Mohamed, N., Rateb, M., Akil, L., Khadra, I., Glaeser, S., Kämpfer, P., Abdelmohsen, U., & El-Katatny, M. (2023). The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies. Natural Product Research. 37(23), 4063-4068. https://doi.org/10.1080/14786419.2023.2167204


Last updated on 2025-10-06 at 11:48