Journalartikel

Jahr der Veröffentlichung: 2010

Seiten: 138-145

Zeitschrift: Molecular and Cellular Endocrinology

Bandnummer: 315

Heftnummer: 1-2

ISSN: 0303-7207

Open Access Status: Green

DOI Link: https://doi.org/10.1016/j.mce.2009.08.003

Verlag: Elsevier

Abstract: 
Transport of (sulfated) iodothyronines across the plasma membrane is required for their intracellular metabolism. Rat Na+/taurocholate cotransporting polypeptide (Ntcp: Slc10al) has been identified as an important transporter protein. We demonstrate that among the 7 members of the solute carrier family SLC10, only human SLC10A1 mediates sodium-dependent transport of the iodothyronine T4 and iodothyronine sulfates T3S and T4S. In contrast to SLC10A2-7, cells co-expressing SLC10A1 and the deiodinase D1 demonstrate a dramatic increase in T3S and T4S metabolism. The SLC10A1 substrates taurocholate, DHEAS and E3S inhibit T3S and T4S transport. Furthermore, co-transfection of SLC10A1 with CRYM,a well known intracellular iodothyronine-binding protein, results in an enhanced intracellular accumulation of T3S and T4S, indicating that CRYM binds iodothyronine sulfates.The present findings indicate that the liver-specific transporter SLC10A1 transports (sulfated) iodothyronines, thereby increasing their intracellular availability. Therefore, SLC10A1 may fulfill a critical step in providing liver D1 with iodothyronine sulfates for rapid degradation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Harvard-Zitierstil: Visser, W., Wong, W., van Mullem, A., Friesema, E., Geyer, J. and Visser, T. (2010) Study of the transport of thyroid hormone by transporters of the SLC10 family, Molecular and Cellular Endocrinology, 315(1-2), pp. 138-145. https://doi.org/10.1016/j.mce.2009.08.003

APA-Zitierstil: Visser, W., Wong, W., van Mullem, A., Friesema, E., Geyer, J., & Visser, T. (2010). Study of the transport of thyroid hormone by transporters of the SLC10 family. Molecular and Cellular Endocrinology. 315(1-2), 138-145. https://doi.org/10.1016/j.mce.2009.08.003