Journalartikel

Jahr der Veröffentlichung: 2017

Seiten: 207-221

Zeitschrift: The Journal of Steroid Biochemistry and Molecular Biology

Bandnummer: 172

ISSN: 0960-0760

DOI Link: https://doi.org/10.1016/j.jsbmb.2016.07.002

Verlag: Elsevier

Abstract: 
Sulfated steroid hormones, such as dehydroepiandrosterone sulfate or estrone-3-sulfate, have long been regarded as inactive metabolites as they cannot activate classical steroid receptors. Some of them are present in the blood circulation at quite high concentrations, but generally sulfated steroids exhibit low membrane permeation due to their hydrophilic properties. However, sulfated steroid hormones can actively be imported into specific target cells via uptake carriers, such as the sodium-dependent organic anion transporter SOAT, and, after hydrolysis by the steroid sulfatase (so-called sulfatase pathway), contribute to the overall regulation of steroid responsive organs.To investigate the biological significance of sulfated steroid hormones for reproductive processes in humans and animals, the research group "Sulfated Steroids in Reproduction" was established by the German Research Foundation DFG (FOR1369). Projects of this group deal with transport of sulfated steroids, sulfation of free steroids, desulfation by the steroid sulfatase, effects of sulfated steroids on steroid biosynthesis and membrane receptors as well as MS-based profiling of sulfated steroids in biological samples. This review and concept paper presents key findings from all these projects and provides a broad overview over the current research on sulfated steroid hormones in the field of reproduction. (C) 2016 Elsevier Ltd. All rights reserved.

Harvard-Zitierstil: Geyer, J., Bakhaus, K., Bernhardt, R., Blaschka, C., Dezhkam, Y., Fietz, D., et al. (2017) The role of sulfated steroid hormones in reproductive processes, The Journal of Steroid Biochemistry and Molecular Biology, 172, pp. 207-221. https://doi.org/10.1016/j.jsbmb.2016.07.002

APA-Zitierstil: Geyer, J., Bakhaus, K., Bernhardt, R., Blaschka, C., Dezhkam, Y., Fietz, D., Grosser, G., Hartmann, K., Hartmann, M., Neunzig, J., Papadopoulos, D., Sánchez-Guijo, A., Scheiner-Bobis, G., Schuler, G., Shihan, M., Wrenzycki, C., Wudy, S., & Bergmann, M. (2017). The role of sulfated steroid hormones in reproductive processes. The Journal of Steroid Biochemistry and Molecular Biology. 172, 207-221. https://doi.org/10.1016/j.jsbmb.2016.07.002