Journal article

Publication year: 2023

Pages: 707-710

Journal: Journal of Science and Medicine in Sport

Volume number: 26

Issue number: 12

ISSN: 1878-1861

DOI Link: https://doi.org/10.1016/j.jsams.2023.10.007

Publisher: Elsevier

Abstract: 
Interactions between statin therapy and physical exercise complicate effective cardiovascular prevention. Emerging evidence suggests that muscle strain related changes in the expression of the glucocorticoid-induced leucine zipper (GILZ) may be involved. Therefore, we measured GILZ mRNA expression levels in M. vastus lateralis samples of 32 healthy individuals before and after a standardized bout of strength or endurance exercise. Overall, we found a highly significant downregulation of GILZ after exercise training (p < 0.001). Within-subgroup changes were statistically significant only after strength training, supporting the role of muscle (as opposed to cardiocirculatory) strain. If confirmed, this may help fitting training recommendations and medication.

Harvard Citation style: Hecksteden, A., Hoppstädter, J., Bizjak, D., Jerg, A., Kirsten, J., Krüger, K., et al. (2023) Effects of acute exercise and training status on glucocorticoid-induced leucine zipper (GILZ) expression in human skeletal muscle, Journal of Science and Medicine in Sport, 26(12), pp. 707-710. https://doi.org/10.1016/j.jsams.2023.10.007

APA Citation style: Hecksteden, A., Hoppstädter, J., Bizjak, D., Jerg, A., Kirsten, J., Krüger, K., Niess, A., Steinacker, J., & Kiemer, A. (2023). Effects of acute exercise and training status on glucocorticoid-induced leucine zipper (GILZ) expression in human skeletal muscle. Journal of Science and Medicine in Sport. 26(12), 707-710. https://doi.org/10.1016/j.jsams.2023.10.007