Journalartikel

Jahr der Veröffentlichung: 2015

Seiten: 407-422

Zeitschrift: Progress in molecular biology and translational science

Bandnummer: 135

ISSN: 1877-1173

ISBN: 978-0-12-803991-5

DOI Link: https://doi.org/10.1016/bs.pmbts.2015.07.023

Verlag: Elsevier

Serientitel: Progress in Molecular Biology and Translational Science

Abstract: 

Exercise is a form of physiological stress which is known to induce an adaptational response.

It is proposed that both apoptosis and autophagy are processes which are necessary for adaptation to exercise. Apoptosis and autophagy are induced during exercise to limit tissue damage, restore tissue integrity, terminate inflammatory responses, or induce direct signals for adaptation. Apoptosis is induced by specific mediators like reactive oxygen species, cytokines, and hormones. Autophagic pathways are activated by altered proteins/organelles with the aim to conserve and recycle the cellular resources. In this case, the cell is flooded with damaged molecules, the repairing mechanisms are overtaxed, and apoptosis is induced. In conclusion, autophagy seems to be necessary for adaptation by providing locally the conditions for muscle plasticity and apoptosis systemically by mobilizing progenitor cells.

Harvard-Zitierstil: Mooren, F. and Krüger, K. (2015) Exercise, Autophagy, and Apoptosis, Progress in molecular biology and translational science, 135, pp. 407-422. https://doi.org/10.1016/bs.pmbts.2015.07.023

APA-Zitierstil: Mooren, F., & Krüger, K. (2015). Exercise, Autophagy, and Apoptosis. Progress in molecular biology and translational science. 135, 407-422. https://doi.org/10.1016/bs.pmbts.2015.07.023