Journal article

Publication year: 2015

Pages: 407-422

Journal: Progress in molecular biology and translational science

Volume number: 135

ISSN: 1877-1173

ISBN: 978-0-12-803991-5

DOI Link: https://doi.org/10.1016/bs.pmbts.2015.07.023

Publisher: Elsevier

Title of series: Progress in Molecular Biology and Translational Science

Abstract: 

Exercise is a form of physiological stress which is known to induce an adaptational response.

It is proposed that both apoptosis and autophagy are processes which are necessary for adaptation to exercise. Apoptosis and autophagy are induced during exercise to limit tissue damage, restore tissue integrity, terminate inflammatory responses, or induce direct signals for adaptation. Apoptosis is induced by specific mediators like reactive oxygen species, cytokines, and hormones. Autophagic pathways are activated by altered proteins/organelles with the aim to conserve and recycle the cellular resources. In this case, the cell is flooded with damaged molecules, the repairing mechanisms are overtaxed, and apoptosis is induced. In conclusion, autophagy seems to be necessary for adaptation by providing locally the conditions for muscle plasticity and apoptosis systemically by mobilizing progenitor cells.

Harvard Citation style: Mooren, F. and Krüger, K. (2015) Exercise, Autophagy, and Apoptosis, Progress in molecular biology and translational science, 135, pp. 407-422. https://doi.org/10.1016/bs.pmbts.2015.07.023

APA Citation style: Mooren, F., & Krüger, K. (2015). Exercise, Autophagy, and Apoptosis. Progress in molecular biology and translational science. 135, 407-422. https://doi.org/10.1016/bs.pmbts.2015.07.023